Bionano meeting

Nanoparticle Enhanced Radiotherapy: A vision for future cancer care

That’s the title of our first 2014 Institute of Integrative Biology seminar; Monday 6th January, 1 pm in LT2.

The speaker is Dr Fred Currell from Queen’s University Belfast. I met Fred for the first time at the Bionano Symposium at the E-MRS spring conference in Strasbourg.

Let me know if you would like to meet the speaker on Monday afternoon.

Protein Cages as Theranostic Agent Carriers, Sierin Lim

Please contact me if you would like to meet the speaker


Wednesday 6th February, School of Biological Sciences, SR6, 1 pm

Sierin Lim

Division of Bioengineering, School of Chemical and Biomedical Engineering
Nanyang Technological University, 70 Nanyang Drive, Block N1.3, Singapore 637457,


Abstract — Protein cages can be engineered to tailor its function as carriers for therapeutic and diagnostic agents. They are formed by self-assembly of multiple subunits forming hollow spherical cage structures of nanometer size. Due to their proteinaceous nature, the protein cages allow facile modifications on its internal and external surfaces, as well as the subunit interfaces. Modifications on the internal and the external surfaces allow conjugation of small molecule drugs or contrast agent and targeting ligands, respectively. The subunit interaction is of special interest in engineering controlled release property onto the protein cage. Two protein cages, E2 protein and ferritin, are described.



Sierin Lim obtained both her B.S. and Ph.D. degrees from University of California, Los Angeles (UCLA) in Chemical Engineering and Biomedical Engineering, respectively. She joined Nanyang Technological University (NTU) as Assistant Professor at the end of July 2007 after a 2.5-year postdoctoral research at University of California, Irvine (UCI). She was the Singapore recipient of the 2012 Asia Pacific Research Networking Fellowship from the International Federation for Medical and Biological Engineering.

Dr. Lim’s research focuses on the design, engineering, and development of hybrid nano/microscale devices from biological parts by utilizing protein engineering as a tool. In particular, she is interested in self-assembling protein-derived nanocapsules and photosynthetic biological materials. The project scopes range from understanding the self-assembly mechanism of the nanocapsules and engineering theranostic carriers to the improvement of electron transfer efficiency in a photosynthetic electrochemical cell.

Novel imaging techniques for preclinical in vivo stem cell tracking

Tammy Kalber, from UCL Centre for Advanced Biomedical Imaging CABI, will visit the University of Liverpool on Monday, and give a seminar:

Mon 29/10/2012, 1pm

Novel imaging techniques for preclinical in vivo stem cell tracking

Lecture Theatre 1, Life Sciences Building

If you would like to meet Tammy, please contact me ASAP:


Bionano meeting at the spring 2013 E-MRS conference announced

For your calendar: after the great success of Bionano@Nice-2012, a slightly changed team invites you to a Bionano symposium at the 2013 E-MRS conference (May 27-31, 2013);

SPRING 13 Q: Bionanomaterials for imaging, sensing and actuating

List of invited speakers (confirmed):

Symposium organizers:

Teresa Pellegrino, National Nanotechnology Laboratory, Italy

Catherine J. Murphy, Chemical & Life Sciences Laboratory, University of Illinois at Urbana-Champaign, USA

Victor F. Puntes, Institut Catala de Nanotecnologia (ICN), Spain

Raphaël Lévy, Institute of Integrative Biology, The University of Liverpool, UK

Dan Peer, Laboratory of Nanomedicine, Tel Aviv University, Israel

Geneviève Pourroy, IPCMS – Département de Chimie et des Matériaux Inorganiques (DCMI), France

Functional nanoprobes: design and use for sensing and imaging

Hedi Mattoussi and Mathias Brust - Nice, May 2011

Department of Chemistry / Bionano meeting, today 4pm, Brunner theatre

Hedi Mattoussi

Florida State University

Department of Chemistry and Biochemistry Tallahassee, FL 32306


Inorganic nanocrystals (such as luminescent quantum dots, metallic and magnetic nanoparticles) exhibit unique optical and physical properties and they can be highly sensitive to potential interactions with proximal dyes and metal complexes.  We have developed approaches based on covalent and non-covalent self-assembly to conjugate a various biomolecules to CdSe-ZnS core-shell QDs rendered water-soluble using polyethylene glycol (PEG)-based modular multifunctional ligands.  In this presentation, we will focus on three aspects: 1) describe the ligand  design we have developed to promote the transfer of these materials to aqueous media and their conjugation to proteins and peptides; 2) the use of these materials and their bio-conjugates to image intracellular compartments and as sensing assemblies that are specific to target proteins and small molecules; and 3) explore the reverse process where the newly developed ligands are used to promote the synthesis of other nanocrystals such as gold nanoparticles.

Bionano meeting 14/03: Optical Microscopy and Non Linear Spectroscopy

On Monday 14th of February, Eann Patterson, who is just joining us as a new Professor in Engineering, and Heike Arnolds, from the Surface Science centre, will be the speakers of our Bionano meeting.

Join us at 4pm in SR2 (School of Biological Sciences); You can download the poster as a pdf here.