I am in charge of a module entitled “Advanced Skills for Biochemistry“. Our third year Biochemistry (Honours) students take this course. One of their tasks is to prepare and present a poster on a hot topic or technique. I have therefore asked the world (via Twitter) and my colleagues at the Institute of Integrative Biology to come up with suggestions of topics for these posters, as well as references that students could use as a starting point.
[I have done so in previous years too].
- T cell quiescence and activation; suggested by Neill Liptrott. Reference: Metabolic coordination of T cell quiescence and activation; Chapman et al, 2019.
- Microbes and preeclampsia; suggested by Doug Kell. Reference: A Dormant Microbial Component in the Development of Preeclampsia; Kell & Kenny, 2016.
- How drugs get into cells; suggested by Doug Kell. How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion; Kell & Oliver, 2014.
- Microbes and Alzheimer’s Disease; suggested by Doug Kell. Reference: Microbes and Alzheimer’s Disease; Itzhaki et al, 2016.
- Evolutionary covariance for protein structure prediction; suggested by Dan Rigden via email: “The topic of evolutionary covariance, with myriad uses but particularly for protein structure prediction, goes from strength to strength. Unfortunately, Google decided not to make the code available or (I think) to publish anything in a journal [there’s a bit of a separate lesson to the students there]. However, they can read about it here and here. This paper, out this week, is the most similar approach I’m aware of and works extremely well. It has a server (that the students could try…) and the code is available.”
- Synthetic biology for faster enzymes, suggested by Doug Kell. Reference: Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently. Currin et al, 2015.
- Nutraceuticals and longevity, suggested by Doug Kell. Reference: Prolonging healthy aging: Longevity vitamins and proteins; Ames, 2018.
- Mitochondrial Breakups, suggested by Violaine See. The Good and the Bad of Mitochondrial Breakups; Sprenger, 2019
- Signalling controlled by frequency modulation, suggested by Violaine Sée, e.g. this article.
- CryoEM – suggested by Steve Royle via Twitter; advances in electron detectors and software has led to explosion of new fascinating structures. Pat Eyers agrees and provides these examples of CryoEM of the anaphase promoting complex.
- Organoids cultures, suggested by Dada Pisconti, e.g. this review Modeling mouse and human development using organoid cultures
- Oxygen sensing across kingdoms, Masson et al; Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants – see also 2019 Nobel Prize announcement.