The video is fairly similar in tone and message to the EMD Millipore advertising video (https://www.youtube.com/watch?v=CiSC2B8hl1E). It does not address the essential paradox that underpins this technology: how do the particles escape endosomes? and, if they don’t, how do they detect cytosolic mRNA?
In our experience, the particles remain trapped in endosomes and the fluorescence increase is most likely due to degradation of the oligonucleotides by nucleases inside endosomes rather than mRNA detection. We will publish this work in the next few days and I will add a link here.
There are also three relevant PubPeer threads:
Incidentally, a similar question regarding the limit between advertising and scientific publication was asked by George McNamara when he noted that a conflict of interest statement should have been included in the Sticky-flares PNAS paper.