New paper accepted in Nature Materials

Even or odd? The number of functional peptide on a nanoparticle makes a big difference

Even or odd? The number of functional peptide on a nanoparticle makes a big difference

Update: the blog post below was posted on the first of April 2015

There will be a proper press release soon so I can’t tell you too much, but I am really delighted to share with you that we have a paper today accepted in Nature Materials (Impact Factor 36.4). The paper focus on some truly spectacular results that we got last year showing how the Poisson distribution of functional peptides on nanoparticles affect their biological and physico-chemical properties. Specifically, we discovered that particles with an even number of functional peptides behaved very differently from particles with an odd number of peptides per nanoparticles. The effect seems to disappear above ~13 peptides per nanoparticles. The odd nanoparticles, especially 5, 7 and 9,  have remarkable cell-penetrating properties and this could lead to a range of therapeutic applications such as fabricating even better nano-scale Navy Seals to kill the “bad guys”, i.e. cancer cells. Remarkably, while the even gold nanoparticles struggle to get inside mammalian cells, they were able to easily get into plant cells which are normally more difficult to penetrate. This could considerably accelerate the development of nanoparticle-modified trees for street lighting.

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