That is the title of Bogart et al Nano Focus article published yesterday in ACS Nano.
Nanoparticles have the potential to contribute to new modalities in molecular imaging and sensing as well as in therapeutic interventions. In this Nano Focus article, we identify some of the current challenges and knowledge gaps that need to be confronted to accelerate the developments of various applications. Using specific examples, we journey from the characterization of these complex hybrid nanomaterials; continue with surface design and (bio)physicochemical properties, their fate in biological media and cells, and their potential for cancer treatment; and finally reflect on the role of animal models to predict their behavior in humans.
The first discussions about this paper took place during the European Materials Research Society meeting in Strasbourg last year (where several of the authors co-chaired symposium Q).